Researchers are uncovering how disrupted glutamatergic synapses drive diverse forms of intellectual disability, revealing new ...

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications ...

Clinical portfolio, informed by deep and novel synapse biology and pharmacology insights, aims to strengthen neural connections through event-driven pharmacology Lead candidate zelquistinel is ...

In the Alzheimer’s disease brain, synaptic loss correlates with cognitive decline, and is considered a sign of disease progression. But is synaptic loss always bad? Provocative new data from several ...

Synapse labeling strategies involve marking synaptic contact sites with different fluorescent proteins in the pre- and postsynaptic compartments. The interface between these contacts is also labeled, ...

A research team led by Dr. Àlex Bayés, Head of the Molecular Physiology of the Synapse Group at the Institut de Recerca Sant Pau (IR Sant Pau), has achieved what for decades had been an elusive goal: ...

Psychedelics stimulate the growth of synapses outside the brain, scientists show for the first time. Many psychedelics act by binding to serotonin receptor 2. Manor and his team found that these ...