Metacaspases, ancestral homologues of the caspase family, are pivotal cysteine proteases found in a wide range of unicellular organisms, including yeasts, algae, and phytoplankton. These enzymes ...

Cancer-killing T cells have been programmed to have two levels of specificity. First, the T cells have been equipped with a receptor sensitive to a protein that is found only in central nervous system ...

Cells that are about to die send a signal to an executioner protein, but sometimes, those cells can fight back and regenerate ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Cells have the remarkable ability to initiate their own death through a mechanism called programmed cell death, also known as apoptosis. Apoptosis contains sophisticated signalling pathways and ...

A team of researchers at the University of Cologne’s Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that ...

In a human body, cells are constantly making life-or-death decisions. If they make the wrong choice, the result can be cancer. It may be possible to treat diseases by influencing this behavior. In the ...

A University of Montana cell biologist has made exciting progress toward finding a way to “program” cancer cells to die rather than to grow. Mark Grimes, an associate professor in the Division of ...

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed. Aging cells secrete substances known to ...