New mutations in TP53 gene drive resistance to p53-targeted cancer therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
News Medical

How Do Genetic Mutations Cause Disease?

Genetic disorders can occur due to mutations in one gene (monogenic), multiple genes (multifactorial inheritance), and mutation in one or more chromosomes. Point mutations are where one nucleotide in ...

Childhood deafness: Researchers identify over 200 mutations, including previously unknown variants

Deafness, the most common sensorineural hearing loss at all stages of life, occurs either independently or as part of ...
SpaceNews

Spaceflight May Be Associated With DNA Mutations and Increased Risk of Developing Heart Disease and Cancer

Characteristics of Clonal Hematopoiesis (CH) Mutations - a) We identified somatic mutations in known clonal hematopoiesis of indeterminate potential (CHIP) driver genes using peripheral blood ...
Seeking Alpha

OnKure: Looking To Alter PI3K Inhibitor Targeting In Breast Cancer And Beyond

OnKure Therapeutics, Inc. (OKUR) is gearing up for a major event in Q4 of 2024, which is that it intends to release data from its phase 1 PIKture-01 study using OKI-219 for the treatment of solid ...
EurekAlert!

Groundbreaking study suggests that mutations driving evolution are informed by the genome, not random

A groundbreaking study published in this week’s issue of PNAS by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not randomly but more ...
The Scientist

Colorectal Cancer and Childhood Exposure to a Common Gut Bacteria

The team used whole-genome sequencing and cataloged mutational patterns from more than 900 patients with CRC across 11 countries and four continents with intermediate to high incidence of CRC. Among ...