This genetic model suggests otherwise, indicating that coupled gating or other mechanical interactions, rather than CICR, drive activation of uncoupled RyR1 channels. Interestingly, the researchers ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...