One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are segments of noncoding DNA that must be removed from the genetic code ...

Tsukuba, Japan—The advent of next-generation sequencing technologies has accelerated genome analysis across diverse eukaryotic lineages. In particular, long-read sequencing facilitates the assembly of ...

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...