Allyl isothiocyanate, the pungent principle of wasabi and other mustard oils, produces pain by activating TRPA1, an excitatory ion channel on sensory nerve endings. Isothiocyanates are ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

In a recent paper in ACS Central Science, researchers report a strategy for targeting covalent modifications to specific sites on proteins. The modifier molecules use an antibody to target a protein ...

Notably, the paper also includes simulation studies outlining when dDRTC is most effective, positioning it as a practical tool for early hit-to-lead optimization and fragment evolution, in contexts ...